Tonin Overexpression in Mice Diminishes Sympathetic Autonomic Modulation and Alters Angiotensin Type 1 Receptor Response

Background: Tonin, a serine-protease that forms Angiotensin II (AngII) from angiotensinogen, is increased in failing human heart samples. Increased blood pressure (BP) and decreased heart rate (HR) variabilities are associated with higher risk of cardiovascular morbidity. Losartan has been used to r...

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Detalles Bibliográficos
Autores principales: Jara, Zaira Palomino, Icimoto, Marcelo Yudi, Yokota, Rodrigo, Ribeiro, Amanda Aparecida, dos Santos, Fernando, de Souza, Leandro Ezequiel, Watanabe, Ingrid Kazue Mizuno, Franco, Maria do Carmo, Pesquero, Jorge Luiz, Irigoyen, Maria Claudia, Casarini, Dulce Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352559/
https://www.ncbi.nlm.nih.gov/pubmed/30729109
http://dx.doi.org/10.3389/fmed.2018.00365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352559/
https://www.ncbi.nlm.nih.gov/pubmed/30729109
http://dx.doi.org/10.3389/fmed.2018.00365

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