Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site

Notch is a conserved signaling pathway that is essential for metazoan development and homeostasis; dysregulated signaling underlies the pathophysiology of numerous human diseases. Receptor-ligand interactions result in gene expression changes, which are regulated by the transcription factor RBPJ. RB...

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Detalles Bibliográficos
Autores principales: Yuan, Zhenyu, VanderWielen, Bradley D., Giaimo, Benedetto Daniele, Pan, Leiling, Collins, Courtney E., Turkiewicz, Aleksandra, Hein, Kerstin, Oswald, Franz, Borggrefe, Tilman, Kovall, Rhett A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352735/
https://www.ncbi.nlm.nih.gov/pubmed/30673607
http://dx.doi.org/10.1016/j.celrep.2018.12.097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352735/
https://www.ncbi.nlm.nih.gov/pubmed/30673607
http://dx.doi.org/10.1016/j.celrep.2018.12.097

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