Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity. It showed 1.6-fold more potent anti-proliferative activity agains...

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Detalles Bibliográficos
Autores principales: Maher, Mai, Kassab, Asmaa E., Zaher, Ashraf F., Mahmoud, Zeinab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352943/
https://www.ncbi.nlm.nih.gov/pubmed/30688116
http://dx.doi.org/10.1080/14756366.2018.1564046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352943/
https://www.ncbi.nlm.nih.gov/pubmed/30688116
http://dx.doi.org/10.1080/14756366.2018.1564046

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