Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation

Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In higher eukaryotes, it remains unclear how the duration of TF binding to DNA relates to downstream transcriptional output. Here, we address this qu...

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Detalles Bibliográficos
Autores principales: Callegari, Andrea, Sieben, Christian, Benke, Alexander, Suter, David M., Fierz, Beat, Mazza, Davide, Manley, Suliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353211/
https://www.ncbi.nlm.nih.gov/pubmed/30653501
http://dx.doi.org/10.1371/journal.pgen.1007891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353211/
https://www.ncbi.nlm.nih.gov/pubmed/30653501
http://dx.doi.org/10.1371/journal.pgen.1007891

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