Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation sites can recruit downstream signaling proteins containing Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which recognize pho...

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Detalles Bibliográficos
Autores principales: Erickson, Keesha E., Rukhlenko, Oleksii S., Shahinuzzaman, Md, Slavkova, Kalina P., Lin, Yen Ting, Suderman, Ryan, Stites, Edward C., Anghel, Marian, Posner, Richard G., Barua, Dipak, Kholodenko, Boris N., Hlavacek, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353226/
https://www.ncbi.nlm.nih.gov/pubmed/30653502
http://dx.doi.org/10.1371/journal.pcbi.1006706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353226/
https://www.ncbi.nlm.nih.gov/pubmed/30653502
http://dx.doi.org/10.1371/journal.pcbi.1006706

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