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Establishment of a transgenic mouse to model ETV7 expressing human tumors

The ETS transcription factor ETV7 has been characterized as a hematopoietic oncoprotein, which requires cooperating mutations for its leukemogenic activity. Although the ETV7 gene is highly conserved among vertebrates, part of the rodents, including Mus musculus, deleted the Etv7 gene locus. Many hu...

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Detalles Bibliográficos
Autores principales: Numata, Masashi, Klein Geltink, R. I., Grosveld, Gerard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353817/
https://www.ncbi.nlm.nih.gov/pubmed/30478527
http://dx.doi.org/10.1007/s11248-018-0104-z