Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine

Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic inflammation, and promoting pancreatic duct obstruc...

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Detalles Bibliográficos
Autores principales: Murthy, Pranav, Singhi, Aatur D., Ross, Mark A., Loughran, Patricia, Paragomi, Pedram, Papachristou, Georgios I., Whitcomb, David C., Zureikat, Amer H., Lotze, Michael T., Zeh III, Herbert J., Boone, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353831/
https://www.ncbi.nlm.nih.gov/pubmed/30733719
http://dx.doi.org/10.3389/fimmu.2019.00028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353831/
https://www.ncbi.nlm.nih.gov/pubmed/30733719
http://dx.doi.org/10.3389/fimmu.2019.00028

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