USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The diagnostic translocation t(22;11)(q24;12) leads to expression of the chimeric oncoprotein EWS-FLI1 which is uniquely expressed in all tumor cells and...

Descripción completa

Detalles Bibliográficos
Autores principales: Gierisch, Maria E., Pedot, Gloria, Walser, Franziska, Lopez-Garcia, Laura A., Jaaks, Patricia, Niggli, Felix K., Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353870/
https://www.ncbi.nlm.nih.gov/pubmed/30700749
http://dx.doi.org/10.1038/s41598-018-37264-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353870/
https://www.ncbi.nlm.nih.gov/pubmed/30700749
http://dx.doi.org/10.1038/s41598-018-37264-5

Ejemplares similares