Next-generation muscle-directed gene therapy by in silico vector design

There is an urgent need to develop the next-generation vectors for gene therapy of muscle disorders, given the relatively modest advances in clinical trials. These vectors should express substantially higher levels of the therapeutic transgene, enabling the use of lower and safer vector doses. In th...

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Detalles Bibliográficos
Autores principales: Sarcar, S., Tulalamba, W., Rincon, M. Y., Tipanee, J., Pham, H. Q., Evens, H., Boon, D., Samara-Kuko, E., Keyaerts, M., Loperfido, M., Berardi, E., Jarmin, S., In’t Veld, P., Dickson, G., Lahoutte, T., Sampaolesi, M., De Bleser, P., VandenDriessche, T., Chuah, M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353880/
https://www.ncbi.nlm.nih.gov/pubmed/30700722
http://dx.doi.org/10.1038/s41467-018-08283-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353880/
https://www.ncbi.nlm.nih.gov/pubmed/30700722
http://dx.doi.org/10.1038/s41467-018-08283-7

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