Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

Pneumococcal infections remain a leading cause of death in older adults, with the most serious cases occurring in persons ≥65 years of age. There is an urgent need to investigate molecular pathways underlying these impairments and devise new therapeutics to modulate innate immunity. The goal of our...

Descripción completa

Detalles Bibliográficos
Autores principales: Plataki, Maria, Cho, Soo Jung, Harris, Rebecca M., Huang, Hua-Rong, Yun, Ha Seon, Schiffer, Kristen T., Stout-Delgado, Heather W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353918/
https://www.ncbi.nlm.nih.gov/pubmed/30700745
http://dx.doi.org/10.1038/s41598-018-37438-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353918/
https://www.ncbi.nlm.nih.gov/pubmed/30700745
http://dx.doi.org/10.1038/s41598-018-37438-1

Ejemplares similares