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Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms o...

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Detalles Bibliográficos
Autores principales: Kalli, Maria, Minia, Angeliki, Pliaka, Vaia, Fotis, Christos, Alexopoulos, Leonidas G., Stylianopoulos, Triantafyllos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353927/
https://www.ncbi.nlm.nih.gov/pubmed/30700740
http://dx.doi.org/10.1038/s41598-018-37425-6