Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA

Methylation of HBV cccDNA has been detected in vivo and in vitro; however, the mechanism and its effects on HBV replication remain unclear. HBx derived from a 1.2-mer HBV replicon upregulated protein levels and enzyme activities of DNA methyltransferase 1 (DNMT1), 3a, and 3b, resulting in methylatio...

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Detalles Bibliográficos
Autores principales: Lee, Hyehyeon, Jeong, Hyerin, Lee, Sun Young, Kim, Soo Shin, Jang, Kyung Lib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354056/
https://www.ncbi.nlm.nih.gov/pubmed/30518174
http://dx.doi.org/10.14348/molcells.2018.0255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354056/
https://www.ncbi.nlm.nih.gov/pubmed/30518174
http://dx.doi.org/10.14348/molcells.2018.0255

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