Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

We use deep sequencing to identify sources of variation in mRNA splicing in the dorsolateral prefrontal cortex (DLFPC) of 450 subjects from two aging cohorts. Hundreds of aberrant pre-mRNA splicing events are reproducibly associated with Alzheimer’s disease. We also generate a catalog of splicing qu...

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Detalles Bibliográficos
Autores principales: Raj, Towfique, Li, Yang I., Wong, Garrett, Humphrey, Jack, Wang, Minghui, Ramdhani, Satesh, Wang, Ying-Chih, Ng, Bernard, Gupta, Ishaan, Haroutunian, Vahram, Schadt, Eric E., Young-Pearse, Tracy, Mostafavi, Sara, Zhang, Bin, Sklar, Pamela, Bennett, David A., De Jager, Philip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354244/
https://www.ncbi.nlm.nih.gov/pubmed/30297968
http://dx.doi.org/10.1038/s41588-018-0238-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354244/
https://www.ncbi.nlm.nih.gov/pubmed/30297968
http://dx.doi.org/10.1038/s41588-018-0238-1

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