The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer’s disease (AD). In this study, behavioral investigations reveale...

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Detalles Bibliográficos
Autores principales: Gerber, Hermeto, Mosser, Sebastien, Boury-Jamot, Benjamin, Stumpe, Michael, Piersigilli, Alessandra, Goepfert, Christine, Dengjel, Joern, Albrecht, Urs, Magara, Fulvio, Fraering, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354426/
https://www.ncbi.nlm.nih.gov/pubmed/30704515
http://dx.doi.org/10.1186/s40478-019-0660-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354426/
https://www.ncbi.nlm.nih.gov/pubmed/30704515
http://dx.doi.org/10.1186/s40478-019-0660-3

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