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The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer’s disease (AD). In this study, behavioral investigations reveale...
Autores principales: | Gerber, Hermeto, Mosser, Sebastien, Boury-Jamot, Benjamin, Stumpe, Michael, Piersigilli, Alessandra, Goepfert, Christine, Dengjel, Joern, Albrecht, Urs, Magara, Fulvio, Fraering, Patrick C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354426/ https://www.ncbi.nlm.nih.gov/pubmed/30704515 http://dx.doi.org/10.1186/s40478-019-0660-3 |
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