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CSF1R antagonism limits local restimulation of antiviral CD8(+) T cells during viral encephalitis
BACKGROUND: Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial depletion via CSF1R inactivation improves cognition in mouse models of neuroinflammation, but limits virologic control in t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354430/ https://www.ncbi.nlm.nih.gov/pubmed/30704498 http://dx.doi.org/10.1186/s12974-019-1397-4 |