CSF1R antagonism limits local restimulation of antiviral CD8(+) T cells during viral encephalitis

BACKGROUND: Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial depletion via CSF1R inactivation improves cognition in mouse models of neuroinflammation, but limits virologic control in t...

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Detalles Bibliográficos
Autores principales: Funk, Kristen E., Klein, Robyn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354430/
https://www.ncbi.nlm.nih.gov/pubmed/30704498
http://dx.doi.org/10.1186/s12974-019-1397-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354430/
https://www.ncbi.nlm.nih.gov/pubmed/30704498
http://dx.doi.org/10.1186/s12974-019-1397-4

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