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CSF1R antagonism limits local restimulation of antiviral CD8(+) T cells during viral encephalitis

BACKGROUND: Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling. Microglial depletion via CSF1R inactivation improves cognition in mouse models of neuroinflammation, but limits virologic control in t...

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Detalles Bibliográficos
Autores principales:	Funk, Kristen E., Klein, Robyn S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354430/ https://www.ncbi.nlm.nih.gov/pubmed/30704498 http://dx.doi.org/10.1186/s12974-019-1397-4

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