A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime

This study sought to define the transit of cefepime between plasma and cerebral spinal fluid (CSF) in a rat model. Male Sprague-Dawley rats received cefepime intravenously. A total daily dose of 150 mg/kg of body weight/day was administered as a single injection every 24 h for 4 days. Plasma samples...

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Detalles Bibliográficos
Autores principales: Avedissian, Sean N., Pais, Gwendolyn, Joshi, Medha D., Rhodes, Nathaniel J., Scheetz, Marc H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354808/
https://www.ncbi.nlm.nih.gov/pubmed/30700511
http://dx.doi.org/10.1128/mSphere.00595-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354808/
https://www.ncbi.nlm.nih.gov/pubmed/30700511
http://dx.doi.org/10.1128/mSphere.00595-18

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