Cargando…
Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta‐cell K(ATP) channels and stimulate insulin secretion; statins as a test case
AIMS: K(ATP) ion channels play a key role in glucose‐stimulated insulin secretion. However, many drugs block K(ATP) as “off targets” leading to hyperinsulinaemia and hypoglycaemia. As such drugs are often lipophilic, the aim was to examine the relationship between drug lipophilicity (P) and IC (50)...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354820/ https://www.ncbi.nlm.nih.gov/pubmed/30815553 http://dx.doi.org/10.1002/edm2.17 |