Cargando…

A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

Testicular Leydig cells (LCs) are the primary source of circulating androgen in men. As men age, circulating androgen levels decline. However, whether reduced LC steroidogenesis results from specific effects of aging within LCs or reflects degenerative alterations to the wider supporting microenviro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Curley, Michael, Milne, Laura, Smith, Sarah, Jørgensen, Anne, Frederiksen, Hanne, Hadoke, Patrick, Potter, Paul, Smith, Lee B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355079/ https://www.ncbi.nlm.nih.gov/pubmed/30080443 http://dx.doi.org/10.1096/fj.201800612R

Ejemplares similares

Human Adipose-derived Pericytes Display Steroidogenic Lineage Potential in Vitro and Influence Leydig Cell Regeneration in Vivo in Rats
por: Curley, Michael, et al.
Publicado: (2019)

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction
por: Jiang, Mei Hua, et al.
Publicado: (2014)

Relationship of transcriptional markers to Leydig cell number in the mouse testis
por: Rebourcet, Diane, et al.
Publicado: (2019)

Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing
por: Gannon, Anne-Louise, et al.
Publicado: (2019)

Testicular leydig cell tumor revealed by hydrocele
por: Ben Kridis, Wala, et al.
Publicado: (2020)

Styrene Cytotoxicity in Testicular Leydig Cells In Vitro
por: Chung, Jin-Yong, et al.
Publicado: (2022)

Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells
por: Arora, Himanshu, et al.
Publicado: (2022)

Leptin Secreted in the Testicular Microenvironment Promotes the Endogenous Function of Leydig Cells Through Hedgehog Signaling Pathway
por: Arora, Himanshu, et al.
Publicado: (2021)

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity
por: Gannon, Anne-Louise, et al.
Publicado: (2021)

Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis
por: Xu, Wendan, et al.
Publicado: (2017)

Assessment of testicular testosterone production and Leydig cell structure.
por: Ewing, L L, et al.
Publicado: (1981)

Macrophages and Leydig Cells in Testicular Biopsies of Azoospermic Men
por: Goluža, Trpimir, et al.
Publicado: (2014)

Ablation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production
por: Rebourcet, Diane, et al.
Publicado: (2020)

Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells
por: Sararols, Pauline, et al.
Publicado: (2021)

Androgen Action via Testicular Arteriole Smooth Muscle Cells Is Important for Leydig Cell Function, Vasomotion and Testicular Fluid Dynamics
por: Welsh, Michelle, et al.
Publicado: (2010)

Leydig cell testicular tumors: About a case report
por: Chaker, Kays, et al.
Publicado: (2017)

Management of testicular Leydig cell tumor: A case report
por: Zhu, Jianguo, et al.
Publicado: (2018)

The SET protein promotes androgen production in testicular Leydig cells
por: Zhang, B., et al.
Publicado: (2018)

Long-term exposure to polystyrene microplastics triggers premature testicular aging
por: Wu, Deyi, et al.
Publicado: (2023)

Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men
por: O’Hara, Laura, et al.
Publicado: (2015)

Identification of Stem Leydig Cells Derived from Pig Testicular Interstitium
por: Yu, Shuai, et al.
Publicado: (2017)

Precocious Puberty Associated with Testicular Hormone-secreting Leydig Cell Tumor
por: Alagha, Eid, et al.
Publicado: (2019)

Jagged1 intracellular domain modulates steroidogenesis in testicular Leydig cells
por: Kumar, Sudeep, et al.
Publicado: (2020)

Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis
por: Rebourcet, Diane, et al.
Publicado: (2014)

Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice
por: Ponikwicka-Tyszko, Donata, et al.
Publicado: (2020)

Bilateral testicular Leydig cell hyperplasia presented incidentally: A case report
por: Al-zubi, Mohammad, et al.
Publicado: (2021)

Precocious puberty related to Leydig cell testicular tumor: the diagnostic imaging keys
por: Grand, Téodor, et al.
Publicado: (2022)

Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone
por: Luo, Dandan, et al.
Publicado: (2023)

Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation
por: Geminiani, Julio J., et al.
Publicado: (2015)

SRY-Positive 46, XX Testicular Disorder of Sexual Development With Leydig Cell Tumor
por: Osaka, Akiyoshi, et al.
Publicado: (2020)

Leydig Cell Hyperplasia Mimicking a Testicular Tumour in a Patient with Klinefelter Syndrome
por: Newman, Christine, et al.
Publicado: (2019)

Identification of Rat Testicular Leydig Precursor Cells by Single-Cell-RNA-Sequence Analysis
por: Guan, Xiaoju, et al.
Publicado: (2022)

Low-Intensity Pulsed Ultrasound Alleviates Human Testicular Leydig Cell Senescence In Vitro
por: Han, Sha, et al.
Publicado: (2022)

ART outcome in young women with premature ovarian aging
por: Dua, Meenakshi, et al.
Publicado: (2013)

Persistent telomere cohesion protects aged cells from premature senescence
por: Azarm, Kameron, et al.
Publicado: (2020)

Leydig Cell Testicular Tumour Presenting as Isosexual Precocious Pseudopuberty in a 5 Year-old Boy with No Palpable Testicular Mass
por: Méndez-Gallart, Roberto, et al.
Publicado: (2010)

Premature and accelerated aging: HIV or HAART?
por: Smith, Reuben L., et al.
Publicado: (2013)

A single-cell transcriptomic landscape of mouse testicular aging
por: Zhang, Wei, et al.
Publicado: (2022)

The Effects of Imatinib Mesylate on Cellular Viability, Platelet Derived Growth Factor and Stem Cell Factor in Mouse Testicular Normal Leydig Cells
por: Kheradmand, Fatemeh, et al.
Publicado: (2016)

HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?
por: Cohen, Ronald A, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2nipp2kgjbigl10vjmfgnm2h2t