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Understanding the coupling between DNA damage detection and UvrA’s ATPase using bulk and single molecule kinetics
Nucleotide excision repair (NER) protects cells against diverse types of DNA damage, principally UV irradiation. In Escherichia coli, damage is recognized by 2 key enzymes: UvrA and UvrB. Despite extensive investigation, the role of UvrA’s 2 ATPase domains in NER remains elusive. Combining single-mo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Federation of American Societies for Experimental Biology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355085/ https://www.ncbi.nlm.nih.gov/pubmed/30020831 http://dx.doi.org/10.1096/fj.201800899R |