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SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension
Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPR(mt)). A cascade of events occur upon UPR(mt) activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355198/ https://www.ncbi.nlm.nih.gov/pubmed/30642431 http://dx.doi.org/10.7554/eLife.41792 |