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SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPR(mt)). A cascade of events occur upon UPR(mt) activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific...

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Detalles Bibliográficos
Autores principales:	Gao, Kaiyu, Li, Yi, Hu, Shumei, Liu, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355198/ https://www.ncbi.nlm.nih.gov/pubmed/30642431 http://dx.doi.org/10.7554/eLife.41792

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