Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the “head” of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem...

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Detalles Bibliográficos
Autores principales: Tan, Hyon-Xhi, Jegaskanda, Sinthujan, Juno, Jennifer A., Esterbauer, Robyn, Wong, Julius, Kelly, Hannah G., Liu, Yi, Tilmanis, Danielle, Hurt, Aeron C., Yewdell, Jonathan W., Kent, Stephen J., Wheatley, Adam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355240/
https://www.ncbi.nlm.nih.gov/pubmed/30521496
http://dx.doi.org/10.1172/JCI123366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355240/
https://www.ncbi.nlm.nih.gov/pubmed/30521496
http://dx.doi.org/10.1172/JCI123366

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