Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder characterized by accelerated cardiovascular disease with extensive fibrosis. It is caused by a mutation in LMNA leading to expression of truncated prelamin A (progerin) in the nucleus. To investigate the contribution of the en...

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Detalles Bibliográficos
Autores principales: Osmanagic-Myers, Selma, Kiss, Attila, Manakanatas, Christina, Hamza, Ouafa, Sedlmayer, Franziska, Szabo, Petra L., Fischer, Irmgard, Fichtinger, Petra, Podesser, Bruno K., Eriksson, Maria, Foisner, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355303/
https://www.ncbi.nlm.nih.gov/pubmed/30422822
http://dx.doi.org/10.1172/JCI121297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355303/
https://www.ncbi.nlm.nih.gov/pubmed/30422822
http://dx.doi.org/10.1172/JCI121297

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