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Screening of chemical library against whole cell kinome activity via non-radioactive, high throughput kinase assay

Protein kinases play a crucial role in cellular functions by adding phosphate group to the protein substrates. It is an indispensable post-translational modification that regulates intracellular signaling and key cellular processes. They thus serve as an excellent target for chemotherapeutic interve...

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Detalles Bibliográficos
Autores principales: Jain, Ravi, Garg, Swati, Singh, Shailja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355432/
https://www.ncbi.nlm.nih.gov/pubmed/30733929
http://dx.doi.org/10.1016/j.mex.2018.12.003