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Screening of chemical library against whole cell kinome activity via non-radioactive, high throughput kinase assay
Protein kinases play a crucial role in cellular functions by adding phosphate group to the protein substrates. It is an indispensable post-translational modification that regulates intracellular signaling and key cellular processes. They thus serve as an excellent target for chemotherapeutic interve...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355432/ https://www.ncbi.nlm.nih.gov/pubmed/30733929 http://dx.doi.org/10.1016/j.mex.2018.12.003 |