Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study

Methyl (S)-4-(6-amino-9H-purin-9-yl)-2-hydroxybutanoate (DZ2002) is a potent reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH). Due to its ester structure, DZ2002 is rapidly hydrolyzed in rat blood to 4-(6-amino-9H-purin-9-yl)-2-hydroxybutyric acid (DZA) during and after blood sampl...

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Detalles Bibliográficos
Autores principales: Jia, Weiwei, Li, Jing, Du, Feifei, Sun, Yan, Xu, Fang, Wang, Fengqing, Olaleye, Olajide E., Chen, Danghui, Tang, Wei, Zuo, Jianping, Li, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355468/
https://www.ncbi.nlm.nih.gov/pubmed/30740254
http://dx.doi.org/10.1016/j.jpha.2018.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355468/
https://www.ncbi.nlm.nih.gov/pubmed/30740254
http://dx.doi.org/10.1016/j.jpha.2018.09.001

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