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Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?
Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement therapy remain an enigma. Under physiological condi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ferrata Storti Foundation
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355482/ https://www.ncbi.nlm.nih.gov/pubmed/30514798 http://dx.doi.org/10.3324/haematol.2018.206383 |