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Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?

Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement therapy remain an enigma. Under physiological condi...

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Detalles Bibliográficos
Autores principales:	Varthaman, Aditi, Lacroix-Desmazes, Sébastien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2019
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355482/ https://www.ncbi.nlm.nih.gov/pubmed/30514798 http://dx.doi.org/10.3324/haematol.2018.206383

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