Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse. The aim of this study is to identify the immunoglobulin isotypes and receptors responsible for asparagi...

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Detalles Bibliográficos
Autores principales: Rathod, Sanjay, Ramsey, Manda, Relling, Mary V., Finkelman, Fred D., Fernandez, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355496/
https://www.ncbi.nlm.nih.gov/pubmed/30237274
http://dx.doi.org/10.3324/haematol.2018.199448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355496/
https://www.ncbi.nlm.nih.gov/pubmed/30237274
http://dx.doi.org/10.3324/haematol.2018.199448

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