Omadacycline Gut Microbiome Exposure Does Not Induce Clostridium difficile Proliferation or Toxin Production in a Model That Simulates the Proximal, Medial, and Distal Human Colon

A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome and the subsequent potential to induce simulated Clostridium difficile infection (CDI). Triple-stage chemostat gut models were inoculated with pool...

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Detalles Bibliográficos
Autores principales: Moura, Ines B., Buckley, Anthony M., Ewin, Duncan, Shearman, Sharie, Clark, Emma, Wilcox, Mark H., Chilton, Caroline H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355569/
https://www.ncbi.nlm.nih.gov/pubmed/30455242
http://dx.doi.org/10.1128/AAC.01581-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355569/
https://www.ncbi.nlm.nih.gov/pubmed/30455242
http://dx.doi.org/10.1128/AAC.01581-18

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