Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model

Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 μg/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 μg/ml (...

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Detalles Bibliográficos
Autores principales: Stainton, Sean M., Monogue, Marguerite L., Tsuji, Masakatsu, Yamano, Yoshinori, Echols, Roger, Nicolau, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355589/
https://www.ncbi.nlm.nih.gov/pubmed/30420477
http://dx.doi.org/10.1128/AAC.01040-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355589/
https://www.ncbi.nlm.nih.gov/pubmed/30420477
http://dx.doi.org/10.1128/AAC.01040-18

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