Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model

Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 μg/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 μg/ml (...

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Detalles Bibliográficos
Autores principales: Stainton, Sean M., Monogue, Marguerite L., Tsuji, Masakatsu, Yamano, Yoshinori, Echols, Roger, Nicolau, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355589/
https://www.ncbi.nlm.nih.gov/pubmed/30420477
http://dx.doi.org/10.1128/AAC.01040-18
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author Stainton, Sean M.
Monogue, Marguerite L.
Tsuji, Masakatsu
Yamano, Yoshinori
Echols, Roger
Nicolau, David P.
author_facet Stainton, Sean M.
Monogue, Marguerite L.
Tsuji, Masakatsu
Yamano, Yoshinori
Echols, Roger
Nicolau, David P.
author_sort Stainton, Sean M.
collection PubMed
description Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 μg/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 μg/ml (n = 11), sustained kill was observed at 72 h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 samples, 1.8%) at 72 h. Adaptive resistance during therapy was not observed.
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spelling pubmed-63555892019-02-01 Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model Stainton, Sean M. Monogue, Marguerite L. Tsuji, Masakatsu Yamano, Yoshinori Echols, Roger Nicolau, David P. Antimicrob Agents Chemother Pharmacology Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 μg/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 μg/ml (n = 11), sustained kill was observed at 72 h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 samples, 1.8%) at 72 h. Adaptive resistance during therapy was not observed. American Society for Microbiology 2019-01-29 /pmc/articles/PMC6355589/ /pubmed/30420477 http://dx.doi.org/10.1128/AAC.01040-18 Text en Copyright © 2019 Stainton et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Pharmacology
Stainton, Sean M.
Monogue, Marguerite L.
Tsuji, Masakatsu
Yamano, Yoshinori
Echols, Roger
Nicolau, David P.
Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title_full Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title_fullStr Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title_full_unstemmed Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title_short Efficacy of Humanized Cefiderocol Exposures over 72 Hours against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model
title_sort efficacy of humanized cefiderocol exposures over 72 hours against a diverse group of gram-negative isolates in the neutropenic murine thigh infection model
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355589/
https://www.ncbi.nlm.nih.gov/pubmed/30420477
http://dx.doi.org/10.1128/AAC.01040-18
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