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Small changes in synaptic gain lead to seizure-like activity in neuronal network at criticality

Epilepsy is a neurological disorder characterised by spontaneous recurrent seizures. The mechanisms by which multiple molecular and cellular changes lead to seizures is not well understood. Here, we study cortical seizure generation by simulating the activity of neuron groups in a network using the...

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Detalles Bibliográficos
Autores principales: Du, Jiaxin, Vegh, Viktor, Reutens, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355815/
https://www.ncbi.nlm.nih.gov/pubmed/30705357
http://dx.doi.org/10.1038/s41598-018-37646-9