Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

PGAM5 is a mitochondrial protein phosphatase whose genetic ablation in mice results in mitochondria-related disorders, including neurodegeneration. Functions of PGAM5 include regulation of mitophagy, cell death, metabolism and aging. However, mechanisms regulating PGAM5 activation and signaling are...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruiz, Karen, Thaker, Tarjani M., Agnew, Christopher, Miller-Vedam, Lakshmi, Trenker, Raphael, Herrera, Clara, Ingaramo, Maria, Toso, Daniel, Frost, Adam, Jura, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355839/
https://www.ncbi.nlm.nih.gov/pubmed/30705304
http://dx.doi.org/10.1038/s41467-019-08393-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355839/
https://www.ncbi.nlm.nih.gov/pubmed/30705304
http://dx.doi.org/10.1038/s41467-019-08393-w

Ejemplares similares