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HPLC methods for purity evaluation of man-made single-stranded RNAs
Synthetic RNA oligos exhibit purity decreasing as a function of length, because the efficiency of the total synthesis is the numerical product of the individual step efficiencies, typically below 98%. Analytical methods for RNAs up to the 60 nucleotides (nt) have been reported, but they fall short f...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356003/ https://www.ncbi.nlm.nih.gov/pubmed/30705318 http://dx.doi.org/10.1038/s41598-018-37642-z |