R‐loop formation during S phase is restricted by PrimPol‐mediated repriming

During DNA replication, conflicts with ongoing transcription are frequent and require careful management to avoid genetic instability. R‐loops, three‐stranded nucleic acid structures comprising a DNA:RNA hybrid and displaced single‐stranded DNA, are important drivers of damage arising from such conf...

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Detalles Bibliográficos
Autores principales: Šviković, Saša, Crisp, Alastair, Tan‐Wong, Sue Mei, Guilliam, Thomas A, Doherty, Aidan J, Proudfoot, Nicholas J, Guilbaud, Guillaume, Sale, Julian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356060/
https://www.ncbi.nlm.nih.gov/pubmed/30478192
http://dx.doi.org/10.15252/embj.201899793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356060/
https://www.ncbi.nlm.nih.gov/pubmed/30478192
http://dx.doi.org/10.15252/embj.201899793

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