Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells

Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of glutaminase, we hypothesize that the antitumoral m...

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Detalles Bibliográficos
Autores principales: Saladini, Serena, Aventaggiato, Michele, Barreca, Federica, Morgante, Emanuela, Sansone, Luigi, Russo, Matteo A., Tafani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356289/
https://www.ncbi.nlm.nih.gov/pubmed/30646605
http://dx.doi.org/10.3390/cells8010049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356289/
https://www.ncbi.nlm.nih.gov/pubmed/30646605
http://dx.doi.org/10.3390/cells8010049

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