ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma

MAPK and p14(ARF)–MDM2–p53 pathways are critical in cutaneous melanomas. Here, synergistic combination of the MEK inhibitor, trametinib, with MDM2 inhibitors, nutlin-3/RG7388/HDM201, and the mechanistic basis of responses, for BRAF(V600E) and p53(WT) melanoma cells, are reported. The combination tre...

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Detalles Bibliográficos
Autores principales: Wu, Chiao-En, Koay, Tsin Shue, Esfandiari, Arman, Ho, Yi-Hsuan, Lovat, Penny, Lunec, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356368/
https://www.ncbi.nlm.nih.gov/pubmed/30577494
http://dx.doi.org/10.3390/cancers11010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356368/
https://www.ncbi.nlm.nih.gov/pubmed/30577494
http://dx.doi.org/10.3390/cancers11010003

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