Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human cells, especially at the telomeric level. The presence of oxidative lesions in the DNA can hinder the replication fork and is able to activate the DNA damage response. In this study, we wanted to unders...

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Detalles Bibliográficos
Autores principales: Coluzzi, Elisa, Leone, Stefano, Sgura, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356380/
https://www.ncbi.nlm.nih.gov/pubmed/30609792
http://dx.doi.org/10.3390/cells8010019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356380/
https://www.ncbi.nlm.nih.gov/pubmed/30609792
http://dx.doi.org/10.3390/cells8010019

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