Cargando…
Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest
Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human cells, especially at the telomeric level. The presence of oxidative lesions in the DNA can hinder the replication fork and is able to activate the DNA damage response. In this study, we wanted to unders...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356380/ https://www.ncbi.nlm.nih.gov/pubmed/30609792 http://dx.doi.org/10.3390/cells8010019 |