The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma

The NOTCH pathway regulates neural stem cells and glioma initiating cells (GICs). However, blocking NOTCH activity with γ-secretase inhibitors (GSIs) fails to alter the growth of GICs, as GSIs seem to be active in only a fraction of GICs lines with constitutive NOTCH activity. Here we report loss of...

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Detalles Bibliográficos
Autores principales: Saito, Norihiko, Hirai, Nozomi, Aoki, Kazuya, Suzuki, Ryo, Fujita, Satoshi, Nakayama, Haruo, Hayashi, Morito, Ito, Keisuke, Sakurai, Takatoshi, Iwabuchi, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356490/
https://www.ncbi.nlm.nih.gov/pubmed/30669546
http://dx.doi.org/10.3390/cancers11010121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356490/
https://www.ncbi.nlm.nih.gov/pubmed/30669546
http://dx.doi.org/10.3390/cancers11010121

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