Fragment-Based Structural Optimization of a Natural Product Itampolin A as a p38α Inhibitor for Lung Cancer

Marine animals and plants provide abundant secondary metabolites with antitumor activity. Itampolin A is a brominated natural tyrosine secondary metabolite that is isolated from the sponge Iotrochota purpurea. Recently, we have achieved the first total synthesis of this brominated tyrosine secondary...

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Detalles Bibliográficos
Autores principales: Liang, Jing-wei, Wang, Ming-yang, Wang, Shan, Li, Xin-yang, Meng, Fan-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356581/
https://www.ncbi.nlm.nih.gov/pubmed/30642059
http://dx.doi.org/10.3390/md17010053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356581/
https://www.ncbi.nlm.nih.gov/pubmed/30642059
http://dx.doi.org/10.3390/md17010053

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