Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

Pancreatic cancer is poorly responsive to chemotherapy due to intrinsic or acquired resistance. Our previous study showed that epigenetic modifying enzymes including protein arginine methyltransferase 3 (PRMT3) are dysregulated in gemcitabine (GEM)-resistant pancreatic cancer cells. Here, we attempt...

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Detalles Bibliográficos
Autores principales: Hsu, Ming-Chuan, Pan, Mei-Ren, Chu, Pei-Yi, Tsai, Ya-Li, Tsai, Chia-Hua, Shan, Yan-Shen, Chen, Li-Tzong, Hung, Wen-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356582/
https://www.ncbi.nlm.nih.gov/pubmed/30577570
http://dx.doi.org/10.3390/cancers11010008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356582/
https://www.ncbi.nlm.nih.gov/pubmed/30577570
http://dx.doi.org/10.3390/cancers11010008

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