Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress

Doxorubicin, an anthracycline from Streptomyces peucetius, exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing increases in intracellular reactive oxygen species in the heart. Spinochrome D (SpD) has a structure of 2,3,5,6,8-pentahydr...

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Detalles Bibliográficos
Autores principales: Yoon, Chang Shin, Kim, Hyoung Kyu, Mishchenko, Natalia P., Vasileva, Elena A., Fedoreyev, Sergey A., Stonik, Valentin A., Han, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356724/
https://www.ncbi.nlm.nih.gov/pubmed/30577438
http://dx.doi.org/10.3390/md17010002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356724/
https://www.ncbi.nlm.nih.gov/pubmed/30577438
http://dx.doi.org/10.3390/md17010002

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