Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress

Recent data on Duchenne muscular dystrophy (DMD) show myocyte progenitor’s involvement in the disease pathology often leading to the DMD patient’s death. The molecular mechanism underlying stem cell impairment in DMD has not been described. We created dystrophin-deficient human pluripotent stem cell...

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Detalles Bibliográficos
Autores principales: Jelinkova, Sarka, Fojtik, Petr, Kohutova, Aneta, Vilotic, Aleksandra, Marková, Lenka, Pesl, Martin, Jurakova, Tereza, Kruta, Miriama, Vrbsky, Jan, Gaillyova, Renata, Valášková, Iveta, Frák, Ivan, Lacampagne, Alain, Forte, Giancarlo, Dvorak, Petr, Meli, Albano C., Rotrekl, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356905/
https://www.ncbi.nlm.nih.gov/pubmed/30650618
http://dx.doi.org/10.3390/cells8010053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356905/
https://www.ncbi.nlm.nih.gov/pubmed/30650618
http://dx.doi.org/10.3390/cells8010053

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