Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products

A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure–activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity agains...

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Detalles Bibliográficos
Autores principales: Matsubara, Takehiro, Yokoya, Masashi, Sirimangkalakitti, Natchanun, Saito, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356950/
https://www.ncbi.nlm.nih.gov/pubmed/30577460
http://dx.doi.org/10.3390/md17010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356950/
https://www.ncbi.nlm.nih.gov/pubmed/30577460
http://dx.doi.org/10.3390/md17010003

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