Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells

Therapeutic targeting of estrogen receptor-α (ERα) by the anti-estrogen tamoxifen is standard of care for premenopausal breast cancer patients and remains a key component of treatment strategies for postmenopausal patients. While tamoxifen significantly increases overall survival, tamoxifen resistan...

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Detalles Bibliográficos
Autores principales: Pulliam, Nicholas, Tang, Jessica, Wang, Weini, Fang, Fang, Sood, Riddhi, O’Hagan, Heather M., Miller, Kathy D., Clarke, Robert, Nephew, Kenneth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357000/
https://www.ncbi.nlm.nih.gov/pubmed/30621214
http://dx.doi.org/10.3390/cancers11010043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357000/
https://www.ncbi.nlm.nih.gov/pubmed/30621214
http://dx.doi.org/10.3390/cancers11010043

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